Therefore, it can be an independent prognostic indicator of neuroblastoma.[20] In addition, patients with neuroblastoma can detect the expression levels of neuron-specific enolase (NSE), urinary vanillylmandelic acid (VMA), and lactate dehydrogenase (LDH), aiding in prognostic judgment.[21–23] NSE is present in neurons and cells of neural origin, and is highly sensitive and specific for neuroblastoma. The gene discussed is ENO2; the disease is neuroblastoma.