And the GSVA enrichment results of OV indicated positive relationship between improved immunoreaction and pathways correlated to classical signaling pathway (PI3K/AKT/MTOR, P53, TNFA/NFkB signaling pathways) and immune responses (T/B cell receptor signaling pathways and primary immunodeficiency) (Fig. 2D). The gene discussed is NFKB1; the disease is inborn error of immunity.