HDAC3 and autism spectrum disorder: It is known that Ankrd11 knockdown results in the decreased proliferation of neuronal precursors, however, the phenotypes caused by Ankrd11 knockdown could be rescued by inhibiting histone acetyltransferase or enhancing HDAC3 expression.[9] Therefore, Ankrd11, being recognized as a key chromatin regulator controlling histone acetylation and gene expression during neurodevelopment, may offer a possible interpretation on its association with cognitive dysfunction and autism spectrum disorder.