MSRA and non-small cell lung carcinoma: TAMs can be primarily divided into 2 categories based on their phenotype: M1 as tumor-suppressor and M2 as tumor-promotor.[43] In NSCLC, the reversal of the M1 phenotype to M2 is proved to be effective in overcoming T790M GR.[44,45] Methionine sulfoxide reductase A (MsrA) is a protector of the T790M EGFR protein.