Chronic liver disease (CLD) is associated with hematological abnormalities,[1] the most common being thrombocytopenia,[2,3] defined as a platelet count < 150 × 109/L, with severe thrombocytopenia defined as a platelet count < 50 × 109/L.[2] The main causes of thrombocytopenia in patients with CLD are splenic sequestration and the decreased production of thrombopoietin by the liver.[2] Reduced hepatic thrombopoietin synthesis in patients with CLD results in a reduction of megakaryocytopoiesis, thrombopoiesis, and platelet release into the circulation.[2]. This evidence concerns the gene THPO and Thrombocytopenia.