By inhibiting VEGFA or PI3/Threonine protein kinase (AKT), they in turn prevent cellular angiogenesis, reduce the proliferation of cancer cells, decrease the number of cancer stem cells, induce apoptosis, and regulate oncogene signaling pathways, which determine the growth and further development of cancer.[10] Most significantly, the majority of phytochemicals function as antioxidants, preventing oxidative stress and potential cancerous effects on cells genetic material by scavenging oxygen-free radicals. The gene discussed is VEGFA; the disease is cancer.