EGFR and head and neck squamous cell carcinoma: Numerous studies have shown that Phytochemicals, including Polyphenols, Flavonoids, and Terpenoids, can be used as therapeutic agents to achieve protective and therapeutic effects against HNSCC.[13] Phytochemicals that target epidermal growth factor receptors are a potentially good source of new drugs for the treatment of HNSCC due to the benefits of phytochemicals and their reduced side effects.