CD8A and cancer: XAPI can promote the infiltration and function of CD8 (+) T cells,[43] up-regulate tumor cell apoptosis-promoting genes and down-regulate suppressor genes to induce tumor cell apoptosis.[44] XAPI has a synergistic effect on chemotherapy in the treatment of malignant tumors.[45] However, there is still a lack of multicenter, large sample clinical studies to fully confirm the clinical efficacy and safety of XAPI.