The acupuncture groups were more likely to have improved metabolic indicators of obesity/overweight than the control groups, in terms of body mass index (standardized mean difference [SMD] = −0.45, 95% confidence interval [CI]: −0.69 to −0.21, I2 = 71.4%), body weight (SMD = −0.48, 95% CI: −0.92 to −0.05, I2 = 84.9%), and serum leptin (SMD = −0.34, 95% CI: −0.58 to −0.10, I2 = 91.8%). The gene discussed is LEP; the disease is Obesity.