All individuals in this cohort displayed sparse and brittle hair with trichorrhexis nodosa and tiger‐tail banding pattern, keratosis pilaris, dry skin, dysplastic nails, hypogonadism, osteoporosis, microcephaly, and intellectual deficit, indicating these as the most consistent clinical findings of MPLKIP‐associated NPS‐TTD (Fig 2; Table EV1 and Materials and Methods). This evidence concerns the gene MPLKIP and microcephaly.