NOP2 was initially explored as an important protein for ribosome synthesis and processing and 60s ribosomal subunit synthesis in budding yeast.14 Recently, NOP2 has been associated with ribosome biogenesis in humans15 and increased expression in most cancers resulting in a poor prognosis.16 NOP2 was found to have elevated expression in ovarian cancer compared to normal controls and was associated with poor prognosis.17 Moreover, NOP2 enhances the proliferation, migration and invasion in colon cancer.18 However, research on the mechanism of NOP2 in HGSOC has not yet been reported. This evidence concerns the gene NOP2 and malignant colon neoplasm.