NOP2 has been described to enhance the cell proliferation, migration and invasive ability of colon cancer,18 and is associated with poor prognosis in renal clear cell carcinoma, gastric adenocarcinoma and ovarian cancer.17,48,49 To date, mechanistic studies of NOP2 in ovarian cancer have not yet been reported. The gene discussed is NOP2; the disease is malignant colon neoplasm.