In a mouse model of colitis, skeletal muscle mass and muscle fiber cross-sectional area decreased and muscle protein content decreased in the quadriceps femoris and gastrocnemius muscles.63 At the same time, muscle dysfunction worsens and the muscle growth markers Insulin-like growth factor 1 receptor (IGF-1 R) and phospho-mammalian target of rapamycin (mTOR) are downregulated.64 Researchers believe that inflammation caused by dysregulation of the gut microbiota may be a triggering factor for skeletal muscle atrophy. This evidence concerns the gene MTOR and colitis.