SCFAs can reduce arthritis severity by regulating IL-10 secretion from Treg cells.203 Butyric acid produced by Lactobacillus inhibits OA by controlling chondrocyte autophagy and inflammatory cell death.204 Probiotic-derived butyrate has been shown to inhibit mouse arthritis by influencing T and B cell progression.205. This evidence concerns the gene IL10 and arthritic joint disease.