Furthermore, biological correlations of proposed gene function with phenotype were not obvious, except in the case of obesity and LANCL3. This gene has been linked to carbohydrate metabolism/high fat diet induced obesity in rats, is expressed in the hypothalamus and has been shown to escape X inactivation in TS, so further investigation may be warranted (32, 42). This evidence concerns the gene LANCL3 and obesity due to melanocortin 4 receptor deficiency.