For DM, potential “risk” genes were MIR4769 and F8, whereas “protective” genes were DOCK11 and STEEP1. In the obesity group, LANCL3, a hypothalamic expressed gene associated with carbohydrate metabolism (42) and RPL36A−HNRNPH2 were potential risk genes. Here, LANCL3 is linked to obesity due to melanocortin 4 receptor deficiency.