AKT1 and chronic obstructive pulmonary disease: Hoenderdos et al. (2016) discovered that inhibiting the PI3K signaling pathway contributes to the suppression of neutrophil degranulation, suggesting that PI3K plays a crucial role in this process. Additionally, inhibiting Akt phosphorylation had no impact on degranulation regulation, implying that heightened neutrophil reactivity is a result of early PI3K/Akt signaling. Yanagisawa et al. (2017) demonstrated that PI3K signaling is more active in bronchial epithelial cells of COPD patients.