Furthermore, dysregulation of the PI3K/Akt signaling pathway is implicated in a diverse spectrum of human diseases, including cancer (Noorolyai et al., 2019), neurodegenerative disease (Rai et al., 2019), diabetes (Huang et al., 2018), and osteoarthritis (Sun et al., 2020). Here, AKT1 is linked to diabetes mellitus.