AKT1 and chronic obstructive pulmonary disease: Xuefu Zhuyu Decoction (XFZYD) is also widely used in the treatment of COPD, and (Hu et al., 2022) and others have found that XFZYD is effective in the treatment of COPD by interfering with the PI3K/Akt signaling pathway, improving oxidative stress and inflammatory responses, and relieving airway remodeling and ventilation disorders through web-based pharmacology and molecular docking experiments.