Additionally, it is also involved in many chronic diseases such as diabetes (Savova et al., 2023), cardiovascular diseases (Qin et al., 2021), neurological disorders (Wang Q. et al., 2022), autoimmune diseases (Cheng et al., 2022), inflammatory diseases (Xu et al., 2022), and liver diseases (Ye et al., 2023) et al. The PI3K/AKT pathway plays a crucial role in the onset and progression of numerous diseases. The gene discussed is AKT1; the disease is diabetes mellitus.