IL1A and breast cancer: BioC, WST, and BC significantly downregulated the mRNA expressions of IL-1α, IL-1β, IL-6, and TNF-α (P < 0.001 or 0.01) and protein levels of IL-6 (P < 0.001) and TNF-α (P < 0.001, 0.01, and 0.05, respectively) in LPS-stimulated RAW264.7 cells (Fig. 4a and b).