Second, to explore the role and significance of FoxO6 in cardiac pathophysiological regulation, we will attempt to construct various mouse cardiac disease models, including myocardial infarction, ischemia–reperfusion injury, coronary atherosclerosis, and diabetic cardiomyopathy models with FoxO6 overexpression or knockout. The gene discussed is FOXO6; the disease is diabetic cardiomyopathy.