As shown in Figure 3, GLM were used to explore the associations between urinary nicotine metabolites and cognitive function, and adjusted for potential confounders (gender, age, education level, hypertension, hyperlipidemia, diabetes, smokers, passive smokers, alcohol consumption, noon break, BUN, SUA, SCr, TBill, ALT, AST and urine creatinine). The gene discussed is GPT; the disease is hyperlipidemia.