Studies suggest that the loss of ovarian hormones during menopause may increase the risk of AD in women, as androgens play a crucial role in various brain functions, such as neurotransmission, neurodevelopment, survival, protection against oxidative stress, reduction of Aβ peptide levels, and reduced tau hyperphosphorylation (Breijyeh and Karaman, 2020). This evidence concerns the gene MAPT and Alzheimer disease.