MAPT and Alzheimer disease: Alzheimer’s disease (AD), the most common cause of dementia, is a progressive degenerative disorder that attacks the brain’s cells resulting in loss of memory, thinking, and language skills, and changes in behavior with extracellular β-amyloid (Aβ) aggregation and neurofibrillary tangles (NFT) formed by hyperphosphorylated tau (Knopman et al., 2021).