Also, CELF2 is involved in influencing various transcripts, such as different exons of MAPT and NMDAR1 exon five, in the mis-splicing event in myotonic dystrophy type 1, particularly in reducing the inclusion of MAPT exon 10, indicating its role in alternative splicing regulation and potential nuclear and cytoplasmic functions in the brain (Liu et al., 2021). The gene discussed is CELF2; the disease is myotonic dystrophy type 1.