A retrospective analysis showed that the overall incidence of pneumonitis in cancer patients receiving treatment with anti-programmed cell death-1/programmed cell death ligand-1 (anti-PD-1/PD-L1) monoclonal antibodies or in combination with anti-cytotoxic T-cell lymphocyte-4 monoclonal antibody was 5% (3%-6%). The gene discussed is CD274; the disease is pneumonitis.