Alzheimer’s disease samples exhibited higher proportions of naive CD4 T cells, resting memory CD4 T cells, resting NK cells, monocytes, neutrophils and macrophages M2, whereas ND samples had higher levels of plasma cells, CD8+ T cells, follicular helper T cells, activated NK cells, and eosinophils. Here, CD8A is linked to early-onset autosomal dominant Alzheimer disease.