The HIF-1α/STAT5 decoy ODN successfully inhibited the target genes of HIF-1α and STAT5, including VEGF, COX-2, iNOS, Bcl-2, Bcl-XL, and cyclin D3, in the in vivo and in vitro AD-like skin disease models (Figures 2 and 7). This evidence concerns the gene CCND3 and Alzheimer disease.