To investigate the effects of HIF-1α/STAT5 in AD, we generated a synthetic HIF-1α/STAT5 decoy ODN, which was designed as a double-stranded nucleotide containing the consensus binding sequences of HIF-1α (HRE; CACGT) and STAT5 (GAS; TTCCCGGAA). The gene discussed is HIF1A; the disease is Alzheimer disease.