Patient's NMOSD has been in remission without relapses, or coexistent infections ever since.<h4>Conclusion</h4>G-CSF is a polyfunctional cytokine with important immunomodulatory effects, which makes it an interesting therapeutic option when autoimmunity coexists with immunodeficiency and was used successfully in this case. The gene discussed is CSF3; the disease is Immunodeficiency.