Angiotensin II, another crucial role of renal fibrosis (Saldanha da Silva et al., 2017), also decreased megalin expression (Mezzano et al., 2001; Hosojima et al., 2009), and the in vivo inhibition of the angiotensin receptor (AT1) with Losartan protected against the reduction of megalin observed in the kidneys of proteinuria animal model (Marzolo and Farfan, 2011). Here, LRP2 is linked to renal fibrosis.