AKT1 and type 2 diabetes mellitus: Interestingly, in early to mid-T2DM/DN, several groups found increases in megalin expression and albumin endocytosis due to the activation of insulin intracellular signaling, including PI3K/AKT, PKB, and mTOR pathways in TECs(Brunskill et al., 1998; Caruso-Neves et al., 2006; Hosojima et al., 2009; Koral et al., 2014; Peruchetti et al., 2014; Coffey et al., 2015; Bryniarski et al., 2018).