They found that in cystinosis, lysosomal dysfunction impairs autophagy’s ability to clear damaged mitochondria, resulting in oxidative stress that stimulates phosphorylation of tight junction ZO-1 by Gα12/Src and triggers a signaling cascade involving ZO-1-associated Y-box factor ZONAB, leading to tubular cell proliferation and transport defects (Festa et al., 2018). Here, TJP1 is linked to cystinosis.