MAGEL2 and Prader-Willi syndrome: PWS is a complex neurogenetic disorder caused by paternal loss of the maternally imprinted 15q11-q13 chromosomal region (called the Prader-Willi region) that contains small nucleolar RNA genes and six protein-coding genes (MKRN3, NDN, NPAP1, SNURF-SNRPN, and MAGEL2) (Butler et al., 2019; Alves and Franco, 2020).