While the loss of MAGEL2 affects regulated secretion in the hypothalamus (Figure 6B), loss of the other Prader-Willi region genes also impacts the clinical presentation of PWS (Cassidy and Driscoll, 2009; Fon Tacer and Potts, 2017; Chen et al., 2020). Here, MAGEL2 is linked to Prader-Willi syndrome.