In the co-culture conditions between treated-CF and neutrophils (black bars), the presence of neutrophils did not affect the MMP2 activity of CF in the basal state, while the co-culture reduced the effects produced by IFN-β, LPS and LPS + IFN on CF respect MMP2 activity (indicated as black barsand in the graph). The gene discussed is IFNB1; the disease is cystic fibrosis.