CXCL8 and cystic fibrosis: In this regard, previous reports have indicated that LPS increases the expression levels of IL-8 in human CF (Skioldebrand et al., 2017; Li et al., 2021), and in fibroblasts derived from nasal polyps, periodontal ligament, and lung polyps, among others (Zhang et al., 2011; Cho et al., 2014; Zhang and Li, 2015).