We speculate that these differentially expressed claudins genes (CLDN2, CLDN1, CLDN14, CLDN16, CLDN18, CLDN9, CLDN12, CLDN6, CLDN8, CLDN23, CLDN5, CLDN11, CLDN7, and CLDN15) have diagnostic value in colon cancer. Here, CLDN2 is linked to malignant colon neoplasm.