We found that the AUC value of CLDN2, CLDN1, CLDN14, CLDN16, CLDN12, CLDN8, CLDN23, CLDN5, CLDN11, and CLDN7 is above 0.80, indicating that these claudins have strong diagnostic value for colon cancer patients. This evidence concerns the gene CLDN12 and malignant colon neoplasm.