We found that the AUC value of CLDN2, CLDN1, CLDN14, CLDN16, CLDN12, CLDN8, CLDN23, CLDN5, CLDN11, and CLDN7 is above 0.80, indicating that these claudins have strong diagnostic value for colon cancer patients. The gene discussed is CLDN14; the disease is malignant colon neoplasm.