We revealed that the expression of CLDN5 and CLDN11 are positively correlated with angiogenesis, apical junction, apoptosis, epithelial-mesenchymal transition (EMT), and hypoxia, and negatively (Figure 9) correlated with proliferation and stemness, indicating that it may be acted as a supportive and protective factor in COAD. This evidence concerns the gene CLDN5 and colon adenocarcinoma.