Moreover, two SNPs in the noncoding parts of TNF gene have been shown to be important for polygenic obesity in Labrador retriever dogs (Mankowska et al., 2016), whereas two exonic SNPs in the MC4R gene have been linked to body weight in Beagle dogs (Zeng et al., 2014). This evidence concerns the gene MC4R and obesity due to melanocortin 4 receptor deficiency.