Finally, we analyzed several markers routinely clinically used for MPNST diagnosis: S100B and SOX10 (cell identity markers of the peripheral nervous system), H3K27me3 (epigenetic marker of PRC2 dysfunction), Vimentin (mesenchymal cell marker), Ki‐67 (proliferation cell marker), and CD34 (fibroblast and endothelial marker). Here, MKI67 is linked to malignant peripheral nerve sheath tumor.