HMGB1 and respiratory syncytial virus bronchiolitis: RSV infection promotes necroptosis and HMGB1 release by AECs, which can facilitate the secretion of proinflammatory mediators and the activation of the NF-κB and P38 MAPK pathways in immune cells in a paracrine mechanism, thus promoting the inflammatory response that contributes to RSV bronchiolitis pathogenesis [97, 130].