Previous studies showed a modest increase in NSE concentrations during sepsis, with median serum levels of 6.6 [IQR 4.1–13.8] μg/L [45], 18.8 [IQR 13.9 –30.5] μg/L [34], and 30.33 [IQR 19.6–46.5] μg/L [47]. Here, ENO2 is linked to Sepsis.