ACTA2 and idiopathic pulmonary fibrosis: A significant decrease in genes linked with fibroblast activation such as connective tissue growth factor (CTGF), collagen-1α1 (COL-1A1), and smooth muscle alpha-2 actin (ACTA2) was observed in the fibroblasts seeded in IPF-derived hydrogel as compared to stiffer 2D plastic dishes.