In agreement with this, Blokland et al., seeded primary lung fibroblasts derived from non-diseased lung tissue onto a 5% w/v bovine serum albumin (BSA) coated GelMa hydrogels with different stiffnesses mimicking a healthy (± 5 kPa stiffness) or COPD -fibrotic (± 15 kPa stiffness) lung tissue to study the mechanosensory response of fibroblasts to pathological changes due to increased ECM stiffness in the lung microenvironment of COPD patients [111]. Here, ALB is linked to chronic obstructive pulmonary disease.