Here, we found an increased release of the master-regulatory inflammatory cytokine IL-1α and its family member IL-1β from the repairing and differentiating asthma-derived epithelium compared to controls and showed that these cytokines inhibited the ability of primary airway fibroblasts to contract, remodel and organize fibrillar collagen [102, 118]. The gene discussed is IL1B; the disease is asthma.