Along with the genes associated with fibroblast activation, they also observed a significant reduction in the genes associated with fibroblast proliferation, such as DNA topoisomerase II alpha (TOP2A) and marker of proliferation, Ki-67 (MKI67) in both IPF derived fibroblasts and normal human lung fibroblasts due to the reduced stiffness of the soft hydrogel in comparison to the stiff culture plate [107]. The gene discussed is MKI67; the disease is idiopathic pulmonary fibrosis.