To investigate whether TRPA1 expression is associated with ERS and mitochondrial morphological dysfunction during cisplatin-induced AKI in mice, we examined the expression levels of ERS, mitochondrial morphology (division/fusion) related proteins using western blotting, observed mitochondrial damage and morphological changes by TEM, and measured the intra-mitochondrial calcium ion concentration using the Fluo-2 AM calcium ion probe. This evidence concerns the gene TRPA1 and acute kidney injury.