MFN2 and acute kidney injury: As shown in Fig. 3B, the expression levels of mitochondrial fusion-related proteins OPA1, MFN1, and MFN2 were reduced in the kidneys of mice with cisplatin-induced AKI (P < 0.01, P < 0.01, P < 0.001), but HC-030031 reversed these levels (P < 0.05, P < 0.05, P < 0.01).