TRPA1 and acute kidney injury: To verify this hypothesis, this study investigated the role of TRPA1 in regulating calcium homeostasis in the MAM between endoplasmic reticulum (ER) and mitochondria in renal tubular epithelial cells to improve cisplatin-induced AKI using human renal tubular epithelial (HK-2) cells and animal model of cisplatin-induced AKI.