MMP2 and central nervous system cancer: Finally, by investigating high and low invadopodia glioma cell lines, Whitehead et al. [17] identified differential proteomes in EVs cargo, demonstrated that co-culture of high invadopodia-derived EVs with low invadopodia cells increased MMP2 secretion and invadopodia, and showed miRNA changes in recipient cells associated with invadopodia.