CTE is a unique disease that is distinct from Alzheimer’s disease (AD) and other tauopathies; this distinction is based on the type and distribution of p-tau deposition [14, 18], molecular structure of the tau filament [19, 20], specific location and evolution of p-tau isoforms [21, 22], and tau phosphorylation sites [23]. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.