TP53 and glioblastoma: To explore whether protein in EVs can be used as a potential clinical diagnostic marker of GBM, Yang et al. tested the protein secreted by EV in the blood and cerebrospinal fluid of the xenografts in situ mouse model and found that DNM3, p65, and p53 could be detected, which was related to disease progression and survival rate, indicating that EVs can be used as a potential clinical diagnostic marker of GBM [116].