In addition, Shiode et al. [23] found that the TRAF3-NIK axis is related to the prognosis of human intrahepatic cholangiocarcinoma (ICC), and the inactivation of TRAF3 can promote the development of ICC through NIK-mediated hepatocyte transdifferentiation. The gene discussed is TRAF3; the disease is intrahepatic cholangiocarcinoma.