With the aid of TIMER2.0 database, we found that TRAF3 was positively correlated with the expression of ASC (R = 0.09, P<0.05), caspase-1 (R = 0.32, P<0.01) and IL-1β (R = 0.37, P<0.01) in lung adenocarcinoma (Fig. 5A). The gene discussed is IL1B; the disease is lung adenocarcinoma.