Recommended serological tests for CD include anti-deamidated gliadin peptide IgA/IgG (DGP IgA/DGP IgG), anti-endomysium IgA (EMA) and anti-tTG IgA antibodies; these laboratory tests are especially useful in individuals without gastrointestinal symptoms, those with conditions associated with CD, and for screening asymptomatic first-degree relatives of known cases [14]. Here, TGM2 is linked to Cowden disease.