MAP4K4 and familial pancreatic carcinoma: Through multi-omics analysis that combines methylation and expression profiling data, compelling evidence has emerged regarding the upregulation of specific genes in pancreatic cancer tissues associated with their hypomethylation status, including sulfotransferase family 1E member 1 (SULT1E1), insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) and mitogen-activated protein 4 kinase 4 (MAP4K4) [59].