Elevation of pro-angiogenic factors like vascular endothelial growth factor (VEGF) and matrix metalloproteionase-2 (MMP-2) and inhibition of anti-angiogenic modulators like sFlt-1 and sEng, facilitate adequate trophoblast invasion and fetoplacental circulation, thus reducing hypertensive disorders [71, 72]. Here, VEGFA is linked to hypertensive disorder.