TGFB1 and neoplasm: They express, albeit not specifically, a number of factors and pathways associated with recruitment of immune cells, angiogenesis, myofibroblast activation and extracellular matrix (ECM) remodeling, including fibroblast-activation protein (FAP), CXCL12, Lox, TGF-β and Hedgehog pathways, all of which play a role in tumor progression12–14.