Notably, and similar to the data obtained in mice models, common genes of the leading edge in the four human datasets included genes regulating or expressed by tumor macrophages, such as AXL, CSF1, CSF1R, CD14 and MSR1, and genes encoding cytokines and cytokine receptors of the OSM, IL-6 and PDGF pathways, as well as genes encoding structural and regulatory proteins of the ECM with essential roles in tissue remodeling and angiogenesis, including collagens, laminins, HSPG2, HAS2, KDR and NOX4. The gene discussed is NOX4; the disease is neoplasm.