Specifically localized in the perivascular niche at the tumor margins, ADAM12+ cells were major producers of factors regulating monocyte recruitment and macrophage function and polarization, including Ccl2, Csf1 and Has2, as well as bridging molecules enhancing macrophage efferocytosis, such as Gas6, and promoted macrophage efferocytosis in an AXL-dependent way. Here, ADAM12 is linked to neoplasm.