Depletion of ADAM12+ cells starting 10 d after tumor implantation, when tumors were palpable, resulted in 50% inhibition of tumor growth (Fig. 1d and Extended Data Fig. 1l; efficiency of depletion of ADAM12+ cells is shown in ref. 27 and Extended Data Fig. 1j,k). The gene discussed is ADAM12; the disease is neoplasm.