ADAM12 and neoplasm: Analysis of the leading edge (i.e., genes accounting for a pathway being defined as enriched) in the pathways ‘Cytokine–cytokine receptor interaction’, ‘ECM–receptor interaction’, ‘Inflammatory response’ and ‘Tissue remodeling’ further identified a number of shared genes in the four tumor datasets (Fig. 6b–e), suggesting that there is a shared gene expression program across solid tumors grouped by ADAM12 expression.