By removing doxycycline at different stages of tumorigenesis (Fig. 5d), we observed that ADAM12+ cells induced at early tumor stages in prostate and pancreatic tumors had increased stromal progenitor potential (Fig. 5f, early, and Extended Data Fig. 7e), compared with ADAM12+ cells at later tumor stages (Fig. 5f, late, and Extended Data Fig. 7e). Here, ADAM12 is linked to neoplasm.