Finally, four studies involved inputs of change of glycaemic variables (HbA1c trajectories, glycaemia during a mixed meal test, continuous glucose monitoring features)33–35, one study focused on fasting GLP-1, GIP and ghrelin levels36, and two studies focused on behavioural traits such as novelty seeking, harm avoidance, and hospital anxiety and depression scale. The gene discussed is GHRL; the disease is major depressive disorder.