More recent guidelines have suggested differential glucose-lowering therapies on the basis of higher body mass index (BMI) (favouring use of glucagon-like peptide analogue, GLP-1) or presence or absence of cardiovascular and/or renal disease and/or heart failure (favouring GLP-1 and/or sodium-glucose co-transporter 2, SGLT-2 inhibitors)3. This evidence concerns the gene GCG and heart failure.