Finally, four studies involved inputs of change of glycaemic variables (HbA1c trajectories, glycaemia during a mixed meal test, continuous glucose monitoring features)33–35, one study focused on fasting GLP-1, GIP and ghrelin levels36, and two studies focused on behavioural traits such as novelty seeking, harm avoidance, and hospital anxiety and depression scale. This evidence concerns the gene GHRL and depressive disorder.