GSTM1 present enhances CDDP detoxification of cells4 and the alleles A of XPC c.2815A>C22, G of XPD c.934G>A23, A of XPD c.2251A>C23, T of XPF c.2505T>C24, and C of TP53 c.215G>C29 SNVs induce greater DNA repair and less apoptosis of damaged cells, respectively, favoring higher survival of tumor cells and lower survival of HNSCC patients. Here, TP53 is linked to neoplasm.