XPD c.934AA genotype was associated with lower EFS (HR: 2.12) and OS (HR: 2.04), but XPF c.2505T>C did not alter the survival of 90 HNSCC patients treated with CDDP and/or RT in a previous analysis of this prospective study, which focused on SNVs on genes of NER pathway15. This evidence concerns the gene ERCC4 and head and neck squamous cell carcinoma.