Only 2 out of the 101 (1.98%) normal prostate cores stained positive (staining intensity score >= 1) for ACAA2 while 93 of the 163 (57%) prostate cancer cores (including localised, adeno-CRPC, and NEPC) stained positive for ACAA2 (P < 10-4), demonstrating ACAA2’s selective elevation in cancerous phenotypes (Supplementary Fig. S2). This evidence concerns the gene ACAA2 and Familial prostate cancer.