None of the benign prostate tissues, only 2 out of 50 (4%) localised prostate cancer samples, and 10 out of 86 (12%) in adeno-CRPC stained high for ACAA2, which is significantly lower than the 11 out of 27 (41%) of NEPC samples (Fig. 3c). This evidence concerns the gene ACAA2 and Familial prostate cancer.