Expression levels of ERVs were increased in the plasma of TP53mut patients after the first cycle of DR-CHOP treatment (p all <0.001, Fig. 6a), accompanied by increased serum concentrations of IFN-α (p = 0.048), IFN-β (p < 0.001), IFN-γ (p < 0.001, Fig. 6b), and elevated frequencies of CD3+CD4+T (p < 0.001) and CD3+CD8+T cells (p = 0.001, Fig. 6c) in the DR-CHOP-responding patients with TP53mut DLBCL. This evidence concerns the gene IFNB1 and diffuse large B-cell lymphoma.