Consistent with our results, in mouse embryonic stem cells, 69 ERV subfamilies were de-repressed in the SETDB1 knockout cells, and only 5 were de-repressed in the DNMT1/DNMT3A/DNMT3B triple knockout cells, indicating that the majority of ERVs were controlled by histone methylation rather than DNA methylation.38 Indeed, in TP53mut DLBCL cell lines and PDX murine models, we illustrated that decitabine induced ERV expression through the down-regulation of SUV39H1 and inhibition of H3K9me3. The gene discussed is SETDB1; the disease is diffuse large B-cell lymphoma.