E2F1 and diffuse large B-cell lymphoma: As per the literature review, the expression of E2F1 is up-regulated in TP53-knockdown cells.29 In our study, E2F1 expression levels were significantly higher in TP53mut DLBCL patients (Supplementary Fig. 4d) and TP53mut cell lines (Supplementary Fig. 4e and 4f) than TP53wt counterparts.