IFNA1 and diffuse large B-cell lymphoma: On the contrary, up-regulation of ERVs (Fig. 6d), as well as IFN production (Fig. 6e) and T cell activation (Fig. 6f), were not observed among TP53mut patients after the first cycle of R-CHOP, highlighting the essential role of epigenetic activation of ERVs in TP53mut DLBCL.