Among major H3K9 lysine methyltransferases [including SUV39 family (SUV39H1, SUV39H2, SETDB1, SETDB2, G9a, and GLP) and PRDM family members (PRDM2, PRDM3, PRDM8, and PRDM16)],24 only SUV39H1 expression was positively correlated with H3K9me3 score (p < 0.001, Fig. 3d and Supplementary Fig. 3b) and significantly higher in TP53mut DLBCL than in TP53wt DLBCL patients (p = 0.020, Fig. 3e), with SUV39H1 protein expression increased by immunohistochemistry in TP53mut DLBCL (p = 0.043, Supplementary Fig. 3c). The gene discussed is SETDB2; the disease is diffuse large B-cell lymphoma.