Diffuse large B-cell lymphoma (DLBCL) represents the most common subtype of non-Hodgkin lymphoma and TP53 mutation (TP53mut) is an important unfavorable genetic alteration,1 predominantly occurring in the DNA binding domain (DBD).2 Functionally, TP53 mutants are classified as structural mutants (R175, R249, G245, and Y220) and DNA contact surface mutants (R248 and R273). The gene discussed is TP53; the disease is non-Hodgkin lymphoma.