Differential expression of genes (DEG) analysis using Wilcoxon rank test, performed between the Dx enriched AML-blast cell clusters (MPO+, CD34+, AZU+) and EOI enriched non-blast cell clusters from Dx and EOI time-points, respectively (Fig. 1d), identified a set of 232 significantly DEGs (Fold Change (FC) > 1.2, adjusted P < 0.01). The gene discussed is MPO; the disease is acute myeloid leukemia.