The module score based on the 7-gene signature effectively distinguished potential AML-blast cells from non-blast cells with only cluster 3 (MPO+) and cluster 5 (AZU1+) displaying positive module scores (Supplementary Fig. 6b, c) upon integrated analysis of Dx, EOI and Rel samples (patients 5 and 6). Here, MPO is linked to acute myeloid leukemia.