TRH and acute myeloid leukemia: Overexpressed genes in the RUNX+ patient’s Dx blast cells included IFITM1, IFITM3, TRH, MPO, TUBB, and CD74. While interferon-inducible transmembrane proteins member, IFITM3, has been reported to be associated with adverse AML prognosis in adults when only chemotherapy is given36, it may have a different role in pediatric AML-blasts.