Consistently with our data but in a cancer setting, Seo et al demonstrated the TAS2R involvement in the extrinsic regulation of stem cell functions.15 They showed that TAS2R over-expression in neuroblastoma cells is associated with the inhibition of their stemness characteristics; specifically, upregulation of endogenous TAS2R8 and TAS2R10 inhibited the expression of various cancer stem cell markers, including DLK1, CD133, Sox2, and Notch1, induces neuronal cell differentiation and inhibits self-renewal capacity. This evidence concerns the gene SOX2 and neuroblastoma.