Hence, to assess the biological effect of TAS2R activation on UBC-derived CD34+ cells, we decided to use denatonium benzoate, a widely used bitter taste agonist,30,37-41 which we demonstrated to modify the transcriptomic profile and functions of acute myeloid leukemia cells.17 Our results demonstrate that UBC-derived CD34+ cells are responsive to TAS2R activation by DEN. The gene discussed is CD34; the disease is acute myeloid leukemia.