CD8A and cancer: Coculture of MCCcells with CD8+ T cells or PBMCs demonstrated increased IFNγproduction, T-cell expansion, and targeted cancer cell killing with4-1BBL/IL-12 NPs compared to controls (Figures 3A,B, S6), withgreater differences seen in MCC13 and UISO compared to MCC26 due tolower baseline T cell-mediated killing.