One potentialadvantage of local autocrine delivery of IFNγ to tumor cellsis stronger MHC-I induction compared to bulk dosing of IFNγin the surrounding environment; therefore, to assess the effect oflocal delivery of IFNγ on MHC-I induction, we compared 4-1BBL/IL-12/IFNγNPs to conditions with up to 10-fold higher concentration of solublerecombinant IFNγ than the maximum amount produced by the 4-1BBL/IL-12/IFNγNPs. This evidence concerns the gene IFNG and neoplasm.