CD8A and neoplasm: Immunohistochemistry(IHC) demonstrated few or no CD8+ T cells (pink) in tumors that receivedcontrol NPs with or without anti-PD1, but tumors receiving both anti-PD1and 4-1BBL/IL-12 NPs or 4-1BBL/IL-12/IFNγ NPs revealed significantCD8+ T-cell infiltration distributed peritumorally and throughoutthe tumor bulk (Figure S9A).