Although latent antigens, such as LMP1 and LMP2A, have been shown to play a key role in EBV-driven cancers, including NPC and GC (Leong and Lung, 2021), the contribution of lytic phase to viral-driven carcinogenesis is now emerging, based on several evidences (Manners et al., 2018). The gene discussed is PDLIM7; the disease is cancer.