For instance, based on a human cancer gene list,52 individual CAG-A3B tumors reported here have APOBEC3 signature mutations in several established cancer genes including Apc (Glu2182Lys) and Plcg1 (Glu1163Lys), as well as APOBEC3-associated events in other cancer genes such as a frameshift mutation in a TC motif in Nf2 (Glu541fs). Here, APC is linked to cancer.