STAT3 and hydrops fetalis: Western blot analysis indicated that the expression of Smac protein was significantly decreased in the PSCs+HF, PSCs, fertile HF groups compared to infertile HF and control group (Fig 3A and 3B) (Pv<0.05), as well expression of STAT3 protein was significantly decreased in the PSCs+HF and PSCs groups compared to control group (Pv<0.05) (Fig 3B).