CD8A and central nervous system cancer: There were increased activities of T cells (p<0.001), Th2 (p<0.001), Th17 (p<0.001), cytotoxic cells (p = 0.028), macrophages (p<0.001), and neutrophils (p<0.001) in PRAME-positive gliomas while there was reduced activities of TFH (p<0.001) and CD8 T cell (p<0.001).