However, various oncogenic processes or signals in PRAME-positive gliomas such as E2F targets, G2M mitotic checkpoint, reactive oxidative oxygen species, IL6-JAK-STAT6, angiogenesis, epithelial-mesenchymal transition, and mTORC1 were activated at the lower levels compared to PRAME-negative tumors. The gene discussed is PRAME; the disease is central nervous system cancer.